S
- Sagamore
- Salem
- Salisbury
- Salisbury Plains
- Salisbury Point
- Sandersdale
- Sandisfield
- Sandwich
- Sandy Beach
- Sandy Hill
- Santuit
- Satans Kingdom
- Saugus
- Savin Hill
- Savoy
- Savoy Center
- Saxonville
- Scituate
- Scotland
- Seabrook
- Seconsett Island
- Seekonk
- Segreganset
- Shakerhill
- Shaker Village
- Sharon
- Shattuckville
- Shawsheen Village
- Sheffield
- Shelburne
- Shelburne Falls
- Sheldonville
- Shepardville
- Sherborn
- Shirkshire
- Shirley
- Shooters Island
- Shore Acres
- Shores
- Shrewsbury
- Shutesbury
- Siasconset
- Silver Hill
- Silver Lake
- Silver Shell Beach
- Silver Spring Beach
- Sippowisset
- Sissons Corner
- Sixteen Acres
- Ski Ward
- Sky Farm
- Skyland
- Slades Corner
- Slades Ferry
- Smith Highlands
- Smith Mills
- Somerset
- Somerville
- South Acton
- South Amherst
- Southampton
- South Ashburnham
- South Ashfield
- South Berlin
- Southborough
- South Brewster
- Southbridge
- South Bridgewater
- South Carver
- South Chelmsford
- South Deerfield
- South Dennis
- South Duxbury
- South Egremont
- South Essex
- South Factory Village
- South Foxboro
- South Hadley
- South Halifax
- South Hamilton
- South Hanson
- South Harwich
- South Hawley
- South Lancaster
- South Middleboro
- South Middleton
- South Milford
- South Orleans
- South Peabody
- South Pond
- South Quabbin Villa
- South Row
- South Truro
- Southville
- South Walpole
- South Wareham
- South Wellfleet
- South Wendell
- South Westport
- Southwick
- South Worthington
- South Yarmouth
- Spencer
- Springfield
- Spruce Corner
- Squantum
- Standish
- State Line
- Stearnsville
- Steep Brook
- Sterling
- Sterling Camp Grounds
- Stevens Corner
- Stewartville
- Still River
- Stockbridge
- Stoneham
- Stoughton
- Stow
- Sturbridge
- Sturtevant Mill
- Sudbury
- Summer Heights
- Summit
- Sunderland
- Surfside
- Sutherland Woods
- Sutton
- Swampscott
- Swansea
- Swanson Corners
- Sweets Corner
- Swift River